Division of Nutrition

Nutrition and Metabolism Training Program at MGH

The Mass General Hospital Program in Nutritional Metabolism was formed under the direction of Dr. Steven Grinspoon, Professor Medicine at HMS, a recognized expert in metabolic, body composition and hormonal changes in HIV-infected patients. The Program, with 6 faculty members and two current trainees, is located in 2400 square feet of renovated office space in Charles River Park, adjacent to the Mass General Hospital.

Program Focus

The MGH Program in Nutritional Metabolism was formed in 2002 under the Direction of Dr. Steven Grinspoon, a recognized expert in neuroendocrinology and metabolism. The Program has advanced our understanding of the hormonal mechanisms contributing to and clinical consequences of visceral and ectopic adipose tissue accumulation in obesity and acquired lipodystrophies.

The Program in Nutritional Metabolism, with 7 faculty members, 2 current fellowship trainees, and a staff of 18 is located in 2800 square feet of newly renovated office space in Charles River Park, adjacent to the Mass General Hospital. The goal of this multidisciplinary program is to study hormonal function, nutrient trafficking, and the metabolic consequences of fat redistribution in a broad number of disease conditions, including undemutrition, obesity and acquired lipodystrophy, for exan1ple among HIV-infected patients and children. Related interests include the interplay between adipose tissue and innate immune activation, and the inflammatory basis of cardiovascular diseases. Faculty members, representing a broad array of interests including neuroendocrinology, pediatric endocrinology, infectious diseases, nutrition and radiology, utilize state of the art techniques including insulin clamp, positron emission tomography (PET), magnetic resonance spectroscopy and K-40 isotope studies to determine metabolic function and body composition. Recent studies have investigated the use of a novel hypothalamic peptide to selectively reduce visceral fat in central obesity and a strategy to block inflammation in obesity with TNF-alpha antagonism. Among children with obesity~ the relationship of mitochondrial function to insulin resistance is being studied.

Research Fellow Training

Training is a major focus of the Program in Nutritional Metabolism. Dr. Grinspoon, Program Director has been successful in training research fellows in metabolism-related clinical research for over 20 years and received a K-24 mentoring award from the NIH in this regard. In addition, he is the Principal Investigator of a Harvard Wide Training Grant in Nutritional Metabolism. Nine recent fellows have obtained mentored, K equivalent grants (K23 or KL2/cMERIT), seven of whom, including Dr. Martin Torriani, Dr. Janet Lo, Dr. Virginia Triant, Dr. Sara Looby, Dr. Markella Zanni, Dr. Suman Srinivasa and Dr. Takara Stanley are now faculty members, investigating effects of increased intramyocellular lipid on insulin resistance in HIV-infected patients (Dr. Torriani), subclinical atherosclerosis in HIV disease (Dr. Lo), the incidence of myocardial infarction in HIV (Dr. Triant), effects of menstrual status on CVD in HIV (Dr. Looby), and effects of GHRH 1-44 on steatohepatitis in HIV (Dr. Stanley), the effects of RAAS blockade in HIV (Dr. Srinivasa) and the effects of statins on MACE in HIV (Dr. Zanni).

For further information regarding application contact:

Dr. Steven Grinspoon, Director,
Massachusetts General Hospital Program in Nutritional Metabolism
55 Fruit St., Boston, MA, 02114
Tel.(617) 726-3890
Fax. (617) 726-5072
E-mail: sgrinspoon@partners.org