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15th Annual
Postgraduate Nutrition Symposium

Advances and Novel Targets
in Energy Balance & Obesity

July 9-10, 2014

Obesity is a major public health problem that has reached epidemic proportions in the US and around the world. Obesity is associated with significant morbidity and mortality. In recent years, our understanding of the mechanisms of obesity and novel therapeutic strategies for weight loss has expanded significantly. Advances have been made in our knowledge of energy balance, with respect to the hypothalamic circuitry controlling appetite and energy expenditure, specific fat types, and the role of gastric peptides, sirtuins, bile acids and gut microbiota in appetite, energy balance and regulation of glucose metabolism. This knowledge has led to novel treatment strategies for obesity as well as strategies that target visceral fat.

Click on a red link to open the Webcast of that presentation in a new window.Presentation abstracts are available as downloadable PDF files.

Determinants of Energy Expenditure and Balance

Hideo Makimura, MD, PhD
Harvard Medical School, Massachusetts General Hosptial


W. Allan Walker, M.D.
Conrad Taff Professor of Nutrition & Pediatrics; Director, Division of Nutrition, Harvard Medical School; Director, Mucosal Immunology Laboratory, Massachusetts General Hospital

Steven Grinspoon, MD
Professor of Medicine, Harvard Medical School; Director, MGH Program in Nutritional Metabolism; Co-Director, Nutrition Obesity Research Center at Harvard, Massachusetts General Hospital

Leptin Signaling in Central Appetite Pathways

Rexford S. Ahima, MD, PhD
Professor of Medicine, University of Pennsylvania,
Perelman School of Medicine, Division of Endocrinology, Diabetes and Metabolism

Brown Fat: Critical Determinant of Energy Expenditure
(No recording available)

Aaron Cypess, MD, PhD, MMSc
Assistant Professor, Harvard Medical School; Assistant Investigator and Staff Physician,
Joslin Diabetes Center

Metabolic Flexibility and Substrate Partitioning in Energy Balance

Eric Ravussin, PhD
Boyd Professor, Douglas L. Gordon Chair in Diabetes & Metabolism; Associate Executive Director, Pennington Biomedical Research Center

Gastric Peptides in Energy Balance

David E. Cummings, MD
Professor of Medicine, Senior Investigator, Diabetes & Obesity Center of Excellence, University of Washington

The Effect of Sleep on Energy Balance

Eve Van Cauter, PhD
Professor of Medicine, Frederick H. Rawson Professor, Director, Sleep, Metabolism and Health Center, The University of Chicago

Roundtable Discussion

Current Therapies for Obesity and Fat Accumulation

W. Scott Butsch, MD, MSc,
Harvard Medical School, Massachusetts General Hospital Weight Center

Recently Approved Therapeutics for Obesity

Caroline M. Apovian, MD, FACP, FACN
Professor of Medicine and Pediatrics, Boston University School of Medicine
Director, Nutrition and Weight Management Center;Director, Nutrition and Support Service, Boston Medical Center

Targeting of Visceral and Ectopic Adipose Depots

Steven K. Grinspoon, MD
Professor of Medicine, Harvard Medical School; Director, MGH Program in Nutritional Metabolism; Co-Director, Nutrition Obesity Research Center at Harvard, Massachusetts General Hospital

Dietary Strategies for Weight Loss: More than Just Calories

David S. Ludwig, MD, PhD
Professor of Pediatrics, Harvard Medical School; Professor of Nutrition, Harvard School of Public Health; The John Fielding Crigier Jr. & Mary Adele Crigier Chair in Pediatric Endocrinology, Boston Children’s Hospital

Behavioral Modification in Weight Loss Therapy

John P. Foreyt, PhD
Professor, Departments of Pediatrics, Medicine, and Psychiatry and Behavioral Sciences; Director, Behavioral Medicine Research Center, Baylor College of Medicine

Roundtable Discussion

with Abraham Thomas, MD, MPH
Division Head, Endocrinology, Whitehouse Chair in Endocrinology, Henry Ford Hospital; Chairperson, FDA Endocrinologic and Metabolic Drugs Advisory Committee

Novel Therapeutics to Alter Energy Balance

Miguel Alonso-Alonso, MD
Harvard Medical School, Beth Israel Deaconess Medical Center

Welcome and Introductions

George L. Blackburn, MD, PhD
S. Daniel Abraham Professor of Nutrition, Associate Director of Nutrition, Division of Nutrition, Harvard Medical School; Department of Surgery, Beth Israel Deaconess Medical Center

A Novel Muscle Protein Regulating Energy Balance: Irisin
(No recording available)

Bruce M. Spiegelman, PhD
Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Dana-Farber Cancer Institute, Harvard Medical School

Effects of Gastric Bypass on Energy Therapeutics

Lee M. Kaplan, MD, PhD
Director, Obesity, Metabolism and Nutrition Institute, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School

Novel Effects of Bile Acids on Energy Regulation

Karen K. Ryan, PhD
Assistant Professor, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati

Potential Effects of Altered Gut Microbiota on Energy Balance

Jonathan Krakoff, MD
Chief, Obesity and Diabetes Clinical Research Section, National Institutes of Health

Sirtuins in Metabolism and Energy Balance
(No recording available)

Marcia C. Haigis, PhD
Associate Professor, Department of Cell Biology, Harvard Medical School

Roundtable Discussion 3 and Closing Remarks

This program was supported by an unrestricted educational grant from:

Takeda Pharmaceuticals International, Inc., US Region
The David S. and Karen A. Shapira Foundation
Boston Nutrition Obesity Research Center
The Peanut Institute
The Conrad Taff Teaching Fund
S. Daniel Abraham Teaching Fund

Presented by

Harvard Medical School Division of Nutrition
and Nutrition Obesity Research Center at Harvard
Boston Nutrition Obesity Research Center
Harvard School of Public Health Department of Nutrition

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