The Division of Nutrition
and Harvard Clinical Nutrition Research Center
HARVARD MEDICAL SCHOOL
and
The Department of Nutrition
and the Department of Genetics and Complex Diseases
HARVARD SCHOOL OF PUBLIC HEALTH
Present
The 9th Annual Postgraduate Nutrition Symposium
Obesity and Inflammation
March 21-22, 2007
Daniel Tosteson Medical Education Center
Carl Walter Amphitheater (2nd Floor)
Harvard Medical School
260 Longwood Avenue
Boston
Chairs: Harry Pothoulakis, MD; Gokhan Hotamisligil, MD, PhD;
and Allan Walker, MD
Introduction
Over the past decade, obesity has been linked with inflammation. It is generally accepted that this inflammation may be critically involved in the early onset of components of the metabolic syndrome as well as cancer. Accordingly, having a better understanding of the association of obesity with inflammation may help clinicians deal with the severe complications of obesity.
A panel of world-renowned physicians and researchers will present knowledge on subjects crucial to the understanding of the critical role of inflammation may play in insulin resistance and development of obesity-related pathologies, and the investigation into whether certain dietary/nutritional components may prevent the development and progression of these complications.
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Wednesday, March 21, 2007
|
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| 7:30 AM | Registration & Continental Breakfast | |
| 8:00 | Welcome | W. Allan Walker, M.D. Conrad Taff Professor of Nutrition; Director, Division of Nutrition, Harvard Medical School |
| 8:05 | Keynote Address: Obesity and Inflammation: Integration of Metabolic and Immune Responses |
Gokhan S. Hotamisligil, M.D., PhD, |
|
SESSION I:
HUMAN STUDIES |
Moderator: Gokhan S. Hotamisligil, M.D., PhD | |
| 8:50 | Obesity, Inflammation and Metabolic Disease in Humans | Paresh Dandona, M.D., PhD., Director, Diabetes - Endocrinology Center of Western New York, Distinguished Professor in Medicine, State University of New York (SUNY) at Buffalo |
| 9:20 | Inflammation and Obesity Related Pathologies | Eric Rimm, ScD., Associate Professor of Epidemiology and Nutrition, Harvard School of Public Health |
| 9:50 | Break | |
| 10:15 | Therapeutic Opportunities Targeting Inflammation in Humans | Allison B. Goldfine, M.D., Investigator, Assistant Director, Clinical Research Section, Joslin Diabetes Center |
| 10:45 | Discussion | |
|
SESSION II:
MACROPHAGES AND METABOLIC DISEASE |
Moderator: Andrew S. Greenberg, M.D. | |
| 11:15 | Infiltration of Adipose Tissue by Immune Cells in Obesity: Chicken or Egg? | Haiyan Xu, M.D., PhD., Assistant Professor of Medicine, Endocrinology Division, Brown University, Division of Biology and Medicine, Brown Medical Center |
| 11:45 | Adipocyte Death and Macrophage Infiltration into Adipose Tissue in Obesity |
Andrew S. Greenberg, M.D., Dr. Robert C. and Veronica Atkins, Professorship in Metabolism and Nutrition, Scientist I and Director, Obesity and Metabolism Laboratory, Jean Mayer USDA HNRCA, Tufts University |
| 12:15 | Luncheon | |
| 1:15 | PPARd and Macrophage Responses |
Chih-Hao Lee, Assistant Professor of Genetics and Complex Diseases, Harvard School of Public Health |
| 1:45 | Discussion | |
|
SESSION III:
NEW PATHS INTEGRATING METABOLISM AND INFLAMMATION |
Moderator: Charalabos Pothoulakis, M.D. | |
| 2:15 | Macrophage ER Stress and Atherosclerosis |
Ira Tabas, M.D., Ph.D., Richard J. Stock Professor and Vice-Chair of Research, Department of Medicine, Columbia University; Professor of Medicine and Anatomy & Cell Biology, (in Physiology and Cellular Biophysics), Columbia University |
| 2:45 | Break | |
| 3:00 | Role of Inflammation in Non-Alcoholic Steatohepatiti |
Anna Mae Diehl, M.D., Professor of Medicine; Chief, Division of Gastroenterology; Director, Duke Liver Center, Duke University |
| 3:30 | Neuropeptides, Mesenteric Fat, and Intestinal Inflammation |
Charalabos Pothoulakis, M.D., Director, Gastrointestinal Neuropeptide Center; Professor of Medicine, Harvard Medical School, Division of Gastroenterology, Beth Israel Deaconess Medical Center |
| 4:00 | Discussion and Closing Remarks | |
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Thursday, March 22
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| 7:30 AM | Registration and Continental Breakfast | |
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SESSION IV:
INFLAMMATION AND COMPLICATIONS OF OBESITY |
Moderator: George Blackburn, M.D., Ph.D. | |
| 8:00 | Introduction | George Blackburn, M.D., Ph.D., S. Daniel Abraham Associate Professor of Nutrition; Associate Director, Division of Nutrition, Harvard Medical School |
| 8:05 | The Role of TLR in Obesity and Diabetes |
Jeffrey Flier, M.D., Chief Academic Officer, Harvard Faculty Dean for Academic Affairs, Beth Israel Deaconess Medical Center, George C. Reisman Professor of Medicine, Harvard Medical School |
| 8:35 | IKK & NFkB Pathway in Obesity and Diabetes |
Steven E. Shoelson, M.D., Ph.D., Helen and Morton Adler Chair, Section Head, Cellular & Molecular Physiology, and Associate Director of Research, Joslin Diabetes Center, Professor of Medicine, Harvard Medical School |
| 9:05 | Oxidative Stress in Obesity and Diabetes |
Philip E. Scherer, Ph.D., Director, Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center |
| 9:35 | Discussion | |
| 10:05 | Break | |
|
SESSION V:
LESSONS FROM OTHER DISEASE STATES |
Moderator: Glenn Dranoff, M.D. | |
| 10:30 | Inflammation and Cancer |
Glenn Dranoff, M.D., Associate Professor of Medicine, Harvard Medical School, Dana-Farber Cancer Institute |
| 11:00 | Stress, Inflammation and Neurologic Disease |
Xandra O. Breakefield, Ph.D., Professor, Department of Neurology, Harvard Medical School; Geneticist (Neurology and Radiology), Massachusetts General Hospital |
| 11:30 | Leptin as a Proinflammatory Mediator in Inflammatory Bowel Disease |
Giarnila Fantuzzi, Ph.D., Associate Professor, Department of Human Nutrition, University of Illinois at Chicago |
| 12:00 | Discussion | |
| 12:25 | Closing Remarks | W. Allan Walker, M.D. |
| 12:30 | Symposium Adjourns | |