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Nutrition and Metabolism Training Programs

Program Faculty

Principle Investigator

Steven Grinspoon, M.D. (Director of the Training Grant)

Biographical sketch

Associate Professor of Medicine and Director of the MGH Program in Nutritional Metabolism.

Research Focus: Neuroendocrinology of over and undernutrition, body composition and adipocyte signaling of hypothalamic function, lipodystrophic models of insulin resistance

 Endocrinology and Hormones

Joseph Avruch, M.D.

Biographical sketch

Professor of Medicine at the Harvard Medical School and Chief of the Diabetes Unit at the Massachusetts General Hospital.

Research Focus: Molecular structure, function and regulation of the elements that mediate signal transduction initiated by the insulin receptor

Maria Alexander-Bridges, M.D., Ph.D.

Associate Professor of Medicine in the Diabetes Unit of the Massachusetts General Hospital.

Research Focus: Identification of target genes of DAF-16 relevant to insulin's metabolic functions and insulin's ability to inhibit apoptosis.

William F. Crowley, Jr., M.D.

Professor of Medicine at Harvard Medical School, Director of Clinical Research, Chief of the Reproductive Endocrine Unit at the Massachusetts General Hospital.

Research Focus: Neuroendocrine control of reproduction in the human and the impact of gonadal products including sex steroids and inhibin on various target organs in both men and women.

Marie Demay, M.D.

Associate Professor of Medicine in the MGH Endocrine Unit.

Research Focus: The effects of Vitamin D and its nuclear receptor on development and bone maturation.

Denise Faustman, M.D.

Biographical sketch

Associate Professor of Medicine at Harvard Medical School, Director the Immunobiology Laboratories at the Massachusetts General Hospital.

Research Focus: Investigation of the molecular pathogenesis of autoimmune pancreatic destruction in Type I Diabetes Mellitus

Joel Finkelstein, M.D.

Associate Professor of Medicine at Harvard Medical School and a member of the Endocrine and Mineral Metabolism Units of the MGH.

Research Focus: Use of PTH as an anabolic strategy to increase bone density in osteoporosis.

Professor of Medicine and prior Division Chief of the Endocrine Division and Chair of the Research Strategy Committee of the Beth Israel Deaconess Medical Center.

Research Focus: The effects of leptin on neuroendocrine function in over and undernutrition

Mason Freeman, M.D.

Associate Professor of Medicine, Chief of the Lipid Metabolism Unit and Director of the Nessel Gene Therapy Center of the MGH.

Research Focus: Disorders of lipid metabolism and their contribution to atherosclerosis, with an emphasis on designing novel genetic strategies to treat atherosclerosis

Janet E. Hall, M.D.

Associate Professor of Medicine at Harvard Medical School and Co-Director of the Research Core of the Harvard Medical School Center of Excellence in Women's Health.

Research Focus: Investigation of the physiology and pathophysiology of the neuroendocrine and gonadal components of the reproductive axis in women in health and aging.

Harald Jüppner, M.D.

Biographical sketch

Associate Professor of Medicine in the Endocrine Unit.

Research Focus: Investigation of defects in the human PTH/PTHrP receptor in patients with pseudohypoparathyroidism and other human diseases.

Barbara Kahn, M.D.

Professor of Medicine and Chief of the Endocrine Division at the Beth-Israel Deaconess Medical Center

Research Focus: Investigation of the cellular and molecular mechanisms for insulin resistance in diabetes and obesity and the tissue specific regulation of the expression of the major insulin-regulated glucose transporter, GLUT4

Anne Klibanski, M.D.

Biographical sketch

Professor of Medicine and Director of the Neuroendocrine Unit of the MGH

Research Focus: Effects of undernutrition on bone and investigation of the effects of IGF- I to stimulate bone formation.

Henry Kronenberg, M.D.

Chief of the Endocrine Unit at the Massachusetts General Hospital and Professor of Medicine at the Harvard Medical School

Research Focus: PTHrP signal regulation of bone metabolism and growth.

David M. Nathan, M.D.

Biographical sketch

Director of the Diabetes Center and General Clinical Research Center at the MGH and Professor of Medicine at Harvard Medical School

Research Focus: Treatment and prevention strategies for Type II Diabetes mellitus.

Nutritional Biochemistry, Metabolism and Obesity

Professor of Medicine at Harvard Medical School and Director of the Nutrition/Infection Laboratory at the Beth Israel Deaconess Medical Center

Research Focus: Effects of cytokines (IL-1) on energy expenditure, glucose turnover and protein breakdown

Associate Director of the Harvard Division of Nutrition and the S. Daniel Abraham Chair in Nutrition Medicine at Harvard Medical School

Research Focus: The use of novel drugs to reduce weight and appetite, and the overall health outcomes

Lee Kaplan, M.D., Ph.D.

Biographical sketch

Assistant Professor of Medicine and Director of the MGH Weight Center

Research Focus: Programmed expression of gene expression underlying hepatic steatosis and overall treatment strategies for obesity

Ravi Thadhani, M.D., MPH

Assistant Professor of Medicine and an Assistant Program Director of the MIT GCRC

Research Focus: Hypertensive disorders during pregnancy and regulation of insulin dynamics in pregnancy

Ronald Tompkins, M.D.

Professor of Surgery and Chief, Trauma and Burn Service, Massachusetts General Hospital

Research Focus: Investigation of amino acid metabolism, increased energy expenditure, insulin resistance and desensitization to lipolysis mediated by the beta-3 adrenoreceptor during severe burns.

Cardiovascular Disease, Cancer and Public Health

Julie Buring, D.Sc.

Biographical sketch

Deputy Director of the Department of Preventative Medicine, Brigham and Women's Hospital, and a Professor in the Department of Ambulatory Care and Prevention, Harvard Medical School and in the Department of Epidemiology, Harvard School of Public Health

Research Focus: Epidemiology of cardiovascular disease and cancer in women

Joann Manson, M.D., Ph.D.

Biographical sketch

Professor of Medicine at Harvard Medical School, Chair of the Division of Preventive Medicine at BWH

Research Focus: Women's health and chronic disease epidemiology, particularly the role of lifestyle factors, micronutrient supplementation, and hormone replacement therapy in the prevention of heart disease and stroke

Francine Welty, M.D.

Biographical sketch

Associate Professor of Medicine and Director of the Cardiovascular Care for Women Program at Beth Israel Deaconess Medical Center

Research Focus: Investigation of mutations associated with low LDL cholesterol, and determination of the effect of dietary soy on lipid levels on atherosclerotic markers in post menopausal women.

Professor of Medicine at HMS and the Frederick John Stare Professor of Epidemiology and Nutrition at HSPH

Research Focus: Investigation of dietary factors, using epidemiologic approaches, in the cause and prevention of cardiovascular disease and cancer

Enterocyte Function and Nutrient Absorption

Nancy Andrews, M.D., Ph.D. (Co-Director of the Training Grant)

Biographical sketch

Associate Professor of Pediatrics at Harvard Medical School, an Associate Investigator of the Howard Hughes Medical Institute at Children's Hospital, Boston

Research Focus: Iron metabolism, using mouse genetics to model human iron disorders

Professor of Pediatrics, Director of the Harvard Clinical Nutrition Research Center, and Chairman, Harvard Division of Nutrition

Research Focus: Immune function in the gut, including the development, ontogeny and function of fetal enterocytes.

Genomics

David Altshuler, M.D., Ph.D.

Assistant Professor of Medicine, Director of the Program in Medical and Population Genetics of the Whitehead Institute and the MIT Center for Genome Research.

Research Focus: Characterize and catalogue human genome sequence variation, and test these variants for association to common metabolic diseases.

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Updated 1/25/2015