Nutrition and Metabolism Training Programs
Program Faculty
Principle Investigator |
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Steven Grinspoon, M.D. (Director of the Training Grant) |
Associate Professor of Medicine and Director of the MGH Program in Nutritional Metabolism. |
Research Focus: Neuroendocrinology of over and undernutrition, body composition and adipocyte signaling of hypothalamic function, lipodystrophic models of insulin resistance |
Endocrinology and Hormones |
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Joseph Avruch, M.D. |
Professor of Medicine at the Harvard Medical School and Chief of the Diabetes Unit at the Massachusetts General Hospital. |
Research Focus: Molecular structure, function and regulation of the elements that mediate signal transduction initiated by the insulin receptor |
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Maria Alexander-Bridges, M.D., Ph.D. |
Associate Professor of Medicine in the Diabetes Unit of the Massachusetts General Hospital. |
Research Focus: Identification of target genes of DAF-16 relevant to insulin's metabolic functions and insulin's ability to inhibit apoptosis. |
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William F. Crowley, Jr., M.D. |
Professor of Medicine at Harvard Medical School, Director of Clinical Research, Chief of the Reproductive Endocrine Unit at the Massachusetts General Hospital. |
Research Focus: Neuroendocrine control of reproduction in the human and the impact of gonadal products including sex steroids and inhibin on various target organs in both men and women. |
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Marie Demay, M.D. |
Associate Professor of Medicine in the MGH Endocrine Unit. |
Research Focus: The effects of Vitamin D and its nuclear receptor on development and bone maturation. |
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Denise Faustman, M.D. |
Associate Professor of Medicine at Harvard Medical School, Director the Immunobiology Laboratories at the Massachusetts General Hospital. |
Research Focus: Investigation of the molecular pathogenesis of autoimmune pancreatic destruction in Type I Diabetes Mellitus |
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Joel Finkelstein, M.D. |
Associate Professor of Medicine at Harvard Medical School and a member of the Endocrine and Mineral Metabolism Units of the MGH. |
Research Focus: Use of PTH as an anabolic strategy to increase bone density in osteoporosis. |
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Professor of Medicine and prior Division Chief of the Endocrine Division and Chair of the Research Strategy Committee of the Beth Israel Deaconess Medical Center. |
Research Focus: The effects of leptin on neuroendocrine function in over and undernutrition |
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Mason Freeman, M.D. |
Associate Professor of Medicine, Chief of the Lipid Metabolism Unit and Director of the Nessel Gene Therapy Center of the MGH. |
Research Focus: Disorders of lipid metabolism and their contribution to atherosclerosis, with an emphasis on designing novel genetic strategies to treat atherosclerosis |
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Janet E. Hall, M.D. |
Associate Professor of Medicine at Harvard Medical School and Co-Director of the Research Core of the Harvard Medical School Center of Excellence in Women's Health. |
Research Focus: Investigation of the physiology and pathophysiology of the neuroendocrine and gonadal components of the reproductive axis in women in health and aging. |
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Harald Jüppner, M.D. |
Associate Professor of Medicine in the Endocrine Unit. |
Research Focus: Investigation of defects in the human PTH/PTHrP receptor in patients with pseudohypoparathyroidism and other human diseases. |
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Barbara Kahn, M.D. |
Professor of Medicine and Chief of the Endocrine Division at the Beth-Israel Deaconess Medical Center |
Research Focus: Investigation of the cellular and molecular mechanisms for insulin resistance in diabetes and obesity and the tissue specific regulation of the expression of the major insulin-regulated glucose transporter, GLUT4 |
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Anne Klibanski, M.D. |
Professor of Medicine and Director of the Neuroendocrine Unit of the MGH |
Research Focus: Effects of undernutrition on bone and investigation of the effects of IGF- I to stimulate bone formation. |
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Henry Kronenberg, M.D. |
Chief of the Endocrine Unit at the Massachusetts General Hospital and Professor of Medicine at the Harvard Medical School |
Research Focus: PTHrP signal regulation of bone metabolism and growth. |
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David M. Nathan, M.D. |
Director of the Diabetes Center and General Clinical Research Center at the MGH and Professor of Medicine at Harvard Medical School |
Research Focus: Treatment and prevention strategies for Type II Diabetes mellitus. |
Nutritional Biochemistry, Metabolism and Obesity |
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Professor of Medicine at Harvard Medical School and Director of the Nutrition/Infection Laboratory at the Beth Israel Deaconess Medical Center |
Research Focus: Effects of cytokines (IL-1) on energy expenditure, glucose turnover and protein breakdown |
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Associate Director of the Harvard Division of Nutrition and the S. Daniel Abraham Chair in Nutrition Medicine at Harvard Medical School |
Research Focus: The use of novel drugs to reduce weight and appetite, and the overall health outcomes |
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Lee Kaplan, M.D., Ph.D. |
Assistant Professor of Medicine and Director of the MGH Weight Center |
Research Focus: Programmed expression of gene expression underlying hepatic steatosis and overall treatment strategies for obesity |
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Ravi Thadhani, M.D., MPH |
Assistant Professor of Medicine and an Assistant Program Director of the MIT GCRC |
Research Focus: Hypertensive disorders during pregnancy and regulation of insulin dynamics in pregnancy |
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Ronald Tompkins, M.D. |
Professor of Surgery and Chief, Trauma and Burn Service, Massachusetts General Hospital |
Research Focus: Investigation of amino acid metabolism, increased energy expenditure, insulin resistance and desensitization to lipolysis mediated by the beta-3 adrenoreceptor during severe burns. |
Cardiovascular Disease, Cancer and Public Health |
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Julie Buring, D.Sc. |
Deputy Director of the Department of Preventative Medicine, Brigham and Women's Hospital, and a Professor in the Department of Ambulatory Care and Prevention, Harvard Medical School and in the Department of Epidemiology, Harvard School of Public Health |
Research Focus: Epidemiology of cardiovascular disease and cancer in women |
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Joann Manson, M.D., Ph.D. |
Professor of Medicine at Harvard Medical School, Chair of the Division of Preventive Medicine at BWH |
Research Focus: Women's health and chronic disease epidemiology, particularly the role of lifestyle factors, micronutrient supplementation, and hormone replacement therapy in the prevention of heart disease and stroke |
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Francine Welty, M.D. |
Associate Professor of Medicine and Director of the Cardiovascular Care for Women Program at Beth Israel Deaconess Medical Center |
Research Focus: Investigation of mutations associated with low LDL cholesterol, and determination of the effect of dietary soy on lipid levels on atherosclerotic markers in post menopausal women. |
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Professor of Medicine at HMS and the Frederick John Stare Professor of Epidemiology and Nutrition at HSPH |
Research Focus: Investigation of dietary factors, using epidemiologic approaches, in the cause and prevention of cardiovascular disease and cancer |
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Enterocyte Function and Nutrient Absorption |
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Nancy Andrews, M.D., Ph.D. (Co-Director of the Training Grant) |
Associate Professor of Pediatrics at Harvard Medical School, an Associate Investigator of the Howard Hughes Medical Institute at Children's Hospital, Boston |
Research Focus: Iron metabolism, using mouse genetics to model human iron disorders |
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Professor of Pediatrics, Director of the Harvard Clinical Nutrition Research Center, and Chairman, Harvard Division of Nutrition |
Research Focus: Immune function in the gut, including the development, ontogeny and function of fetal enterocytes. |
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Genomics |
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David Altshuler, M.D., Ph.D. |
Assistant Professor of Medicine, Director of the Program in Medical and Population Genetics of the Whitehead Institute and the MIT Center for Genome Research. |
Research Focus: Characterize and catalogue human genome sequence variation, and test these variants for association to common metabolic diseases. |
